AustralieFrV1, Main, Exploration, bibRecord, 00AA85

Somatic mutations of KIT in familial testicular germ cell tumours

Identifieur interne : 00AA85 ( Main/Exploration ); précédent : 00AA84; suivant : 00AA86

Somatic mutations of KIT in familial testicular germ cell tumours

Auteurs : E. A. Rapley [Royaume-Uni] ; S. Hockley [Royaume-Uni] ; W. Warren [Royaume-Uni] ; L. Johnson [Royaume-Uni] ; R. Huddart [Royaume-Uni] ; G. Crockford [Royaume-Uni] ; D. Forman [Royaume-Uni] ; M. G. Leahy [Royaume-Uni] ; D. T. Oliver [Australie] ; K. Tucker [Australie] ; M. Friedlander [Australie] ; K-A Phillips [Australie] ; D. Hogg [Canada] ; M. A. S. Jewett [Canada] ; R. Lohynska [République tchèque] ; G. Daugaard [Danemark] ; S. Richard [France] ; A. Heidenreich [Allemagne] ; L. Geczi [Hongrie] ; I. Bodrogi [Hongrie] ; E. Olah [Hongrie] ; W. J. Ormiston [Irlande (pays)] ; P. A. Daly [Irlande (pays)] ; L. H. J. Looijenga [Pays-Bas] ; P. Guilford [Nouvelle-Zélande] ; N. Aass [Norvège] ; S. D. Fossa [Norvège] ; K. Heimdal [Norvège] ; S. A. Tjulandin [Russie] ; L. Liubchenko [Russie] ; H. Stoll [Suisse] ; W. Weber [Suisse] ; L. Einhorn [États-Unis] ; B. L. Weber [États-Unis] ; M. Mcmaster [États-Unis] ; M. H. Greene [États-Unis] ; D. T. Bishop [Royaume-Uni] ; D. Easton [Royaume-Uni] ; M. R. Stratton [Royaume-Uni]

Source :

British journal of cancer [ 0007-0920 ] ; 2004.

RBID : Pascal:04-0432585

Descripteurs français

Pascal (Inist)
- Tumeur, Mutation somatique, Testicule, Cellule tumorale, Cancérologie.

English descriptors

KwdEn :
- Cancerology, Somatic mutation, Testicle, Tumor, Tumor cell.

Abstract

Somatic mutations of the KIT gene have been reported in mast cell diseases and gastrointestinal stromal tumours. Recently, they have also been found in mediastinal and testicular germ cell tumours (TGCTs), particularly in cases with bilateral disease. We screened the KIT coding sequence (except exon 1) for germline mutations in 240 pedigrees with two or more cases of TGCT. No germline mutations were found. Exons 10, 11 and 17 of KIT were examined for somatic mutations in 123 TGCT from 93 multiple-case testicular cancer families. Five somatic mutations were identified; four were missense amino-acid substitutions in exon 17 and one was a 12 bp in-frame deletion in exon I 1. Two of seven TGCT from cases with bilateral disease carried KIT mutations compared with three out of I 16 unilateral cases (P=0.026). The results indicate that somatic KIT mutations are implicated in the development of a minority of familial as well as sporadic TGCT. They also lend support to the hypothesis that KIT mutations primarily take place during embryogenesis such that primordial germ cells with KIT mutations are distributed to both testes.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410291

Affiliations:

Le document en format XML

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<author><name sortKey="Phillips, K A" sort="Phillips, K A" uniqKey="Phillips K" first="K-A" last="Phillips">K-A Phillips</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Haematology and Medical Oncology Peter MacCallum Cancer Centre, St Andrews Place</s1>
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<author><name sortKey="Hogg, D" sort="Hogg, D" uniqKey="Hogg D" first="D." last="Hogg">D. Hogg</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Princess Margaret Hospital and University of Toronto, 610 University Avenue</s1>
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<author><name sortKey="Jewett, M A S" sort="Jewett, M A S" uniqKey="Jewett M" first="M. A. S." last="Jewett">M. A. S. Jewett</name>
<affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Princess Margaret Hospital and University of Toronto, 610 University Avenue</s1>
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<author><name sortKey="Lohynska, R" sort="Lohynska, R" uniqKey="Lohynska R" first="R." last="Lohynska">R. Lohynska</name>
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<author><name sortKey="Daugaard, G" sort="Daugaard, G" uniqKey="Daugaard G" first="G." last="Daugaard">G. Daugaard</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Oncology 5073, Rigshospitalet</s1>
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<author><name sortKey="Richard, S" sort="Richard, S" uniqKey="Richard S" first="S." last="Richard">S. Richard</name>
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<author><name sortKey="Heidenreich, A" sort="Heidenreich, A" uniqKey="Heidenreich A" first="A." last="Heidenreich">A. Heidenreich</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Urological Oncology, Phillips University</s1>
<s2>Marburg</s2>
<s3>DEU</s3>
<sZ>18 aut.</sZ>
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<country>Allemagne</country>
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<author><name sortKey="Geczi, L" sort="Geczi, L" uniqKey="Geczi L" first="L." last="Geczi">L. Geczi</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Chemotherapy C and Department of Molecular Genetics National institute of Oncology, Rath Gyorgy u 7, H-1122</s1>
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<s3>HUN</s3>
<sZ>19 aut.</sZ>
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<author><name sortKey="Bodrogi, I" sort="Bodrogi, I" uniqKey="Bodrogi I" first="I." last="Bodrogi">I. Bodrogi</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Chemotherapy C and Department of Molecular Genetics National institute of Oncology, Rath Gyorgy u 7, H-1122</s1>
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<author><name sortKey="Olah, E" sort="Olah, E" uniqKey="Olah E" first="E." last="Olah">E. Olah</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Chemotherapy C and Department of Molecular Genetics National institute of Oncology, Rath Gyorgy u 7, H-1122</s1>
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<author><name sortKey="Ormiston, W J" sort="Ormiston, W J" uniqKey="Ormiston W" first="W. J." last="Ormiston">W. J. Ormiston</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Medical Oncology, St James Hospital</s1>
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<author><name sortKey="Daly, P A" sort="Daly, P A" uniqKey="Daly P" first="P. A." last="Daly">P. A. Daly</name>
<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Medical Oncology, St James Hospital</s1>
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<s3>IRL</s3>
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<author><name sortKey="Looijenga, L H J" sort="Looijenga, L H J" uniqKey="Looijenga L" first="L. H. J." last="Looijenga">L. H. J. Looijenga</name>
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<author><name sortKey="Guilford, P" sort="Guilford, P" uniqKey="Guilford P" first="P." last="Guilford">P. Guilford</name>
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<author><name sortKey="Aass, N" sort="Aass, N" uniqKey="Aass N" first="N." last="Aass">N. Aass</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Oncology, The Norwegian Radium Hospital and Department of Medical Genetics, Rikshospitalet</s1>
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<author><name sortKey="Fossa, S D" sort="Fossa, S D" uniqKey="Fossa S" first="S. D." last="Fossa">S. D. Fossa</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Oncology, The Norwegian Radium Hospital and Department of Medical Genetics, Rikshospitalet</s1>
<s2>0027 Oslo</s2>
<s3>NOR</s3>
<sZ>26 aut.</sZ>
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<author><name sortKey="Heimdal, K" sort="Heimdal, K" uniqKey="Heimdal K" first="K." last="Heimdal">K. Heimdal</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Oncology, The Norwegian Radium Hospital and Department of Medical Genetics, Rikshospitalet</s1>
<s2>0027 Oslo</s2>
<s3>NOR</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
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<country>Norvège</country>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tjulandin, S A" sort="Tjulandin, S A" uniqKey="Tjulandin S" first="S. A." last="Tjulandin">S. A. Tjulandin</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Laboratory of Clinical Genetics, Institute of Clinical Oncology, NN Blokhin Russian Cancer Research Center Kashirskoye sh., 24</s1>
<s2>Moscow  115478</s2>
<s3>RUS</s3>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
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<country>Russie</country>
<wicri:noRegion>Moscow  115478</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liubchenko, L" sort="Liubchenko, L" uniqKey="Liubchenko L" first="L." last="Liubchenko">L. Liubchenko</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Laboratory of Clinical Genetics, Institute of Clinical Oncology, NN Blokhin Russian Cancer Research Center Kashirskoye sh., 24</s1>
<s2>Moscow  115478</s2>
<s3>RUS</s3>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Russie</country>
<wicri:noRegion>Moscow  115478</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stoll, H" sort="Stoll, H" uniqKey="Stoll H" first="H." last="Stoll">H. Stoll</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Clinical Cancer Research Unit, UICC Familial Cancer and Prevention Project Heuberg 16</s1>
<s2>4051 Basel</s2>
<s3>CHE</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4051 Basel</wicri:noRegion>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Somatic mutations of KIT in familial testicular germ cell tumours</title>
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<author><name sortKey="Johnson, L" sort="Johnson, L" uniqKey="Johnson L" first="L." last="Johnson">L. Johnson</name>
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<author><name sortKey="Crockford, G" sort="Crockford, G" uniqKey="Crockford G" first="G." last="Crockford">G. Crockford</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St. James's University Hospital</s1>
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<author><name sortKey="Oliver, D T" sort="Oliver, D T" uniqKey="Oliver D" first="D. T." last="Oliver">D. T. Oliver</name>
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<author><name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M." last="Friedlander">M. Friedlander</name>
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<author><name sortKey="Lohynska, R" sort="Lohynska, R" uniqKey="Lohynska R" first="R." last="Lohynska">R. Lohynska</name>
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<author><name sortKey="Daugaard, G" sort="Daugaard, G" uniqKey="Daugaard G" first="G." last="Daugaard">G. Daugaard</name>
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<country>Danemark</country>
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<author><name sortKey="Richard, S" sort="Richard, S" uniqKey="Richard S" first="S." last="Richard">S. Richard</name>
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<author><name sortKey="Heidenreich, A" sort="Heidenreich, A" uniqKey="Heidenreich A" first="A." last="Heidenreich">A. Heidenreich</name>
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<country>Allemagne</country>
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<author><name sortKey="Geczi, L" sort="Geczi, L" uniqKey="Geczi L" first="L." last="Geczi">L. Geczi</name>
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<author><name sortKey="Olah, E" sort="Olah, E" uniqKey="Olah E" first="E." last="Olah">E. Olah</name>
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<sZ>19 aut.</sZ>
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<affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Department of Medical Oncology, St James Hospital</s1>
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<sZ>22 aut.</sZ>
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<sZ>22 aut.</sZ>
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<author><name sortKey="Guilford, P" sort="Guilford, P" uniqKey="Guilford P" first="P." last="Guilford">P. Guilford</name>
<affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Cancer Genetics Laboratory, University of Otago, PO Box 56</s1>
<s2>Dunedin</s2>
<s3>NZL</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>Nouvelle-Zélande</country>
<wicri:noRegion>Dunedin</wicri:noRegion>
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</author>
<author><name sortKey="Aass, N" sort="Aass, N" uniqKey="Aass N" first="N." last="Aass">N. Aass</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Oncology, The Norwegian Radium Hospital and Department of Medical Genetics, Rikshospitalet</s1>
<s2>0027 Oslo</s2>
<s3>NOR</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Norvège</country>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fossa, S D" sort="Fossa, S D" uniqKey="Fossa S" first="S. D." last="Fossa">S. D. Fossa</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Oncology, The Norwegian Radium Hospital and Department of Medical Genetics, Rikshospitalet</s1>
<s2>0027 Oslo</s2>
<s3>NOR</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Norvège</country>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Heimdal, K" sort="Heimdal, K" uniqKey="Heimdal K" first="K." last="Heimdal">K. Heimdal</name>
<affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Department of Oncology, The Norwegian Radium Hospital and Department of Medical Genetics, Rikshospitalet</s1>
<s2>0027 Oslo</s2>
<s3>NOR</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
<sZ>28 aut.</sZ>
</inist:fA14>
<country>Norvège</country>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tjulandin, S A" sort="Tjulandin, S A" uniqKey="Tjulandin S" first="S. A." last="Tjulandin">S. A. Tjulandin</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Laboratory of Clinical Genetics, Institute of Clinical Oncology, NN Blokhin Russian Cancer Research Center Kashirskoye sh., 24</s1>
<s2>Moscow  115478</s2>
<s3>RUS</s3>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Russie</country>
<wicri:noRegion>Moscow  115478</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liubchenko, L" sort="Liubchenko, L" uniqKey="Liubchenko L" first="L." last="Liubchenko">L. Liubchenko</name>
<affiliation wicri:level="1"><inist:fA14 i1="15"><s1>Laboratory of Clinical Genetics, Institute of Clinical Oncology, NN Blokhin Russian Cancer Research Center Kashirskoye sh., 24</s1>
<s2>Moscow  115478</s2>
<s3>RUS</s3>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>Russie</country>
<wicri:noRegion>Moscow  115478</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stoll, H" sort="Stoll, H" uniqKey="Stoll H" first="H." last="Stoll">H. Stoll</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Clinical Cancer Research Unit, UICC Familial Cancer and Prevention Project Heuberg 16</s1>
<s2>4051 Basel</s2>
<s3>CHE</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
</inist:fA14>
<country>Suisse</country>
<wicri:noRegion>4051 Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weber, W" sort="Weber, W" uniqKey="Weber W" first="W." last="Weber">W. Weber</name>
<affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Clinical Cancer Research Unit, UICC Familial Cancer and Prevention Project Heuberg 16</s1>
<s2>4051 Basel</s2>
<s3>CHE</s3>
<sZ>31 aut.</sZ>
<sZ>32 aut.</sZ>
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<country>Suisse</country>
<wicri:noRegion>4051 Basel</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Einhorn, L" sort="Einhorn, L" uniqKey="Einhorn L" first="L." last="Einhorn">L. Einhorn</name>
<affiliation wicri:level="1"><inist:fA14 i1="17"><s1>Indiana University</s1>
<s2>Indianapolis, IN</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Indiana University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Weber, B L" sort="Weber, B L" uniqKey="Weber B" first="B. L." last="Weber">B. L. Weber</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Abramson Family Cancer Research Institute, University of Pennsylvania</s1>
<s2>PA</s2>
<s3>USA</s3>
<sZ>34 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>PA</wicri:noRegion>
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<author><name sortKey="Mcmaster, M" sort="Mcmaster, M" uniqKey="Mcmaster M" first="M." last="Mcmaster">M. Mcmaster</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute National Institutes of Health, 6110 Executive Boulevard</s1>
<s2>Room Rockvilie, MD 20852-7231</s2>
<s3>USA</s3>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Room Rockvilie, MD 20852-7231</wicri:noRegion>
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<author><name sortKey="Greene, M H" sort="Greene, M H" uniqKey="Greene M" first="M. H." last="Greene">M. H. Greene</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute National Institutes of Health, 6110 Executive Boulevard</s1>
<s2>Room Rockvilie, MD 20852-7231</s2>
<s3>USA</s3>
<sZ>35 aut.</sZ>
<sZ>36 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Room Rockvilie, MD 20852-7231</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bishop, D T" sort="Bishop, D T" uniqKey="Bishop D" first="D. T." last="Bishop">D. T. Bishop</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Genetic Epidemiology Division, Cancer Research UK Clinical Centre, St. James's University Hospital</s1>
<s2>Leeds LS9 7TF</s2>
<s3>GBR</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Leeds LS9 7TF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Easton, D" sort="Easton, D" uniqKey="Easton D" first="D." last="Easton">D. Easton</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Cancer Research UK Genetic Epidemiology Unit, Strangeways Research Laboratory Worts Causeway</s1>
<s2>Cambridge CB1 8RN</s2>
<s3>GBR</s3>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Cambridge CB1 8RN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stratton, M R" sort="Stratton, M R" uniqKey="Stratton M" first="M. R." last="Stratton">M. R. Stratton</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Section of Cancer Genetics Institute of Cancer Research, Brookes Lawley Building, 15 Cotswold Road</s1>
<s2>Sutton, Surrey SM2 5NG</s2>
<s3>GBR</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<wicri:noRegion>Sutton, Surrey SM2 5NG</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">British journal of cancer</title>
<title level="j" type="abbreviated">Br. J. cancer</title>
<idno type="ISSN">0007-0920</idno>
<imprint><date when="2004">2004</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">British journal of cancer</title>
<title level="j" type="abbreviated">Br. J. cancer</title>
<idno type="ISSN">0007-0920</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term>
<term>Somatic mutation</term>
<term>Testicle</term>
<term>Tumor</term>
<term>Tumor cell</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Tumeur</term>
<term>Mutation somatique</term>
<term>Testicule</term>
<term>Cellule tumorale</term>
<term>Cancérologie</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Somatic mutations of the KIT gene have been reported in mast cell diseases and gastrointestinal stromal tumours. Recently, they have also been found in mediastinal and testicular germ cell tumours (TGCTs), particularly in cases with bilateral disease. We screened the KIT coding sequence (except exon 1) for germline mutations in 240 pedigrees with two or more cases of TGCT. No germline mutations were found. Exons 10, 11 and 17 of KIT were examined for somatic mutations in 123 TGCT from 93 multiple-case testicular cancer families. Five somatic mutations were identified; four were missense amino-acid substitutions in exon 17 and one was a 12 bp in-frame deletion in exon I 1. Two of seven TGCT from cases with bilateral disease carried KIT mutations compared with three out of I 16 unilateral cases (P=0.026). The results indicate that somatic KIT mutations are implicated in the development of a minority of familial as well as sporadic TGCT. They also lend support to the hypothesis that KIT mutations primarily take place during embryogenesis such that primordial germ cells with KIT mutations are distributed to both testes.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>Danemark</li>
<li>France</li>
<li>Hongrie</li>
<li>Irlande (pays)</li>
<li>Norvège</li>
<li>Nouvelle-Zélande</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Russie</li>
<li>République tchèque</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Bohême centrale</li>
<li>District de Giessen</li>
<li>Hesse (Land)</li>
<li>Hongrie centrale</li>
<li>Hovedstaden</li>
<li>Nouvelle-Galles du Sud</li>
<li>Ontario</li>
<li>Île-de-France</li>
<li>Østlandet</li>
</region>
<settlement><li>Budapest</li>
<li>Copenhague</li>
<li>Le Kremlin-Bicêtre</li>
<li>Marbourg</li>
<li>Oslo</li>
<li>Prague</li>
<li>Sydney</li>
<li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Rapley, E A" sort="Rapley, E A" uniqKey="Rapley E" first="E. A." last="Rapley">E. A. Rapley</name>
</noRegion>
<name sortKey="Bishop, D T" sort="Bishop, D T" uniqKey="Bishop D" first="D. T." last="Bishop">D. T. Bishop</name>
<name sortKey="Crockford, G" sort="Crockford, G" uniqKey="Crockford G" first="G." last="Crockford">G. Crockford</name>
<name sortKey="Easton, D" sort="Easton, D" uniqKey="Easton D" first="D." last="Easton">D. Easton</name>
<name sortKey="Forman, D" sort="Forman, D" uniqKey="Forman D" first="D." last="Forman">D. Forman</name>
<name sortKey="Hockley, S" sort="Hockley, S" uniqKey="Hockley S" first="S." last="Hockley">S. Hockley</name>
<name sortKey="Huddart, R" sort="Huddart, R" uniqKey="Huddart R" first="R." last="Huddart">R. Huddart</name>
<name sortKey="Johnson, L" sort="Johnson, L" uniqKey="Johnson L" first="L." last="Johnson">L. Johnson</name>
<name sortKey="Leahy, M G" sort="Leahy, M G" uniqKey="Leahy M" first="M. G." last="Leahy">M. G. Leahy</name>
<name sortKey="Stratton, M R" sort="Stratton, M R" uniqKey="Stratton M" first="M. R." last="Stratton">M. R. Stratton</name>
<name sortKey="Warren, W" sort="Warren, W" uniqKey="Warren W" first="W." last="Warren">W. Warren</name>
</country>
<country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Oliver, D T" sort="Oliver, D T" uniqKey="Oliver D" first="D. T." last="Oliver">D. T. Oliver</name>
</region>
<name sortKey="Friedlander, M" sort="Friedlander, M" uniqKey="Friedlander M" first="M." last="Friedlander">M. Friedlander</name>
<name sortKey="Phillips, K A" sort="Phillips, K A" uniqKey="Phillips K" first="K-A" last="Phillips">K-A Phillips</name>
<name sortKey="Tucker, K" sort="Tucker, K" uniqKey="Tucker K" first="K." last="Tucker">K. Tucker</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Hogg, D" sort="Hogg, D" uniqKey="Hogg D" first="D." last="Hogg">D. Hogg</name>
</region>
<name sortKey="Jewett, M A S" sort="Jewett, M A S" uniqKey="Jewett M" first="M. A. S." last="Jewett">M. A. S. Jewett</name>
</country>
<country name="République tchèque"><region name="Bohême centrale"><name sortKey="Lohynska, R" sort="Lohynska, R" uniqKey="Lohynska R" first="R." last="Lohynska">R. Lohynska</name>
</region>
</country>
<country name="Danemark"><region name="Hovedstaden"><name sortKey="Daugaard, G" sort="Daugaard, G" uniqKey="Daugaard G" first="G." last="Daugaard">G. Daugaard</name>
</region>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Richard, S" sort="Richard, S" uniqKey="Richard S" first="S." last="Richard">S. Richard</name>
</region>
</country>
<country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Heidenreich, A" sort="Heidenreich, A" uniqKey="Heidenreich A" first="A." last="Heidenreich">A. Heidenreich</name>
</region>
</country>
<country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Geczi, L" sort="Geczi, L" uniqKey="Geczi L" first="L." last="Geczi">L. Geczi</name>
</region>
<name sortKey="Bodrogi, I" sort="Bodrogi, I" uniqKey="Bodrogi I" first="I." last="Bodrogi">I. Bodrogi</name>
<name sortKey="Olah, E" sort="Olah, E" uniqKey="Olah E" first="E." last="Olah">E. Olah</name>
</country>
<country name="Irlande (pays)"><noRegion><name sortKey="Ormiston, W J" sort="Ormiston, W J" uniqKey="Ormiston W" first="W. J." last="Ormiston">W. J. Ormiston</name>
</noRegion>
<name sortKey="Daly, P A" sort="Daly, P A" uniqKey="Daly P" first="P. A." last="Daly">P. A. Daly</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Looijenga, L H J" sort="Looijenga, L H J" uniqKey="Looijenga L" first="L. H. J." last="Looijenga">L. H. J. Looijenga</name>
</noRegion>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Guilford, P" sort="Guilford, P" uniqKey="Guilford P" first="P." last="Guilford">P. Guilford</name>
</noRegion>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Aass, N" sort="Aass, N" uniqKey="Aass N" first="N." last="Aass">N. Aass</name>
</region>
<name sortKey="Fossa, S D" sort="Fossa, S D" uniqKey="Fossa S" first="S. D." last="Fossa">S. D. Fossa</name>
<name sortKey="Heimdal, K" sort="Heimdal, K" uniqKey="Heimdal K" first="K." last="Heimdal">K. Heimdal</name>
</country>
<country name="Russie"><noRegion><name sortKey="Tjulandin, S A" sort="Tjulandin, S A" uniqKey="Tjulandin S" first="S. A." last="Tjulandin">S. A. Tjulandin</name>
</noRegion>
<name sortKey="Liubchenko, L" sort="Liubchenko, L" uniqKey="Liubchenko L" first="L." last="Liubchenko">L. Liubchenko</name>
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<country name="Suisse"><noRegion><name sortKey="Stoll, H" sort="Stoll, H" uniqKey="Stoll H" first="H." last="Stoll">H. Stoll</name>
</noRegion>
<name sortKey="Weber, W" sort="Weber, W" uniqKey="Weber W" first="W." last="Weber">W. Weber</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Einhorn, L" sort="Einhorn, L" uniqKey="Einhorn L" first="L." last="Einhorn">L. Einhorn</name>
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<name sortKey="Greene, M H" sort="Greene, M H" uniqKey="Greene M" first="M. H." last="Greene">M. H. Greene</name>
<name sortKey="Mcmaster, M" sort="Mcmaster, M" uniqKey="Mcmaster M" first="M." last="Mcmaster">M. Mcmaster</name>
<name sortKey="Weber, B L" sort="Weber, B L" uniqKey="Weber B" first="B. L." last="Weber">B. L. Weber</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Somatic mutations of KIT in familial testicular germ cell tumours

Somatic mutations of KIT in familial testicular germ cell tumours

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